Sphingosomes, a novel class of lipid-based vesicular systems, have emerged as promising carriers in the realm of drug delivery. This review aims to provide an overview of the progressive journey of sphingosomes and their application perspectives in modern drug delivery.The evolution of sphingosomes began with the quest to develop more efficient and biocompatible drug delivery systems. Their unique composition, primarily comprising sphingolipids and cholesterol, imparts stability and modulates membrane fluidity, enhancing their potential as drug carriers. The versatility of sphingosomes allows for the encapsulation of diverse therapeutic agents, ranging from small molecules to biological entities like proteins and nucleic acids.Their biocompatibility and ability to mimic cell membranes grant sphingosomes the advantage of reduced immunogenicity and improved cellular uptake. Moreover, their structural flexibility permits the incorporation of targeting ligands, facilitating site-specific drug delivery and minimizing off-target effects.