Influenza serology assays play a crucial role in understanding the prevalence, transmission, and immune response to influenza viruses. However, the influence of erythrocyte species on the accuracy and reliability of these assays remains understudied. This research aims to explore the impact of hematological variations, particularly erythrocyte species, on influenza serology assays. By evaluating the interactions between different erythrocyte types and assay outcomes, we can gain insights into potential biases and improve the interpretation of serological data. Understanding these nuances is essential for enhancing the effectiveness of influenza surveillance and vaccine development strategies.